When you're finished click on the "Complete" button at the top of the summary view. This will tell the other reviewer that you've finished your assessement. You won't be able to compare assessments until both reviewers have completed their assessments. If you haven't made a judgement against a domain you will see a warning. If the domain is not applicable to the study then you can remove the domain. This won't affect any other study.
You can edit your assessment at any time. To edit a judgement click on the edit icon from the top right hand corner of the judgement view.