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FAQ: Which question framework should I choose?

Setting up a review

FAQ: Which question framework should I choose?

Last updated on 24 Jun, 2026

Your choice of framework depends on the type of research question you're asking. Think about what your review question is asking, who it’s about and what it’s seeking to evaluate.

Framework

Stands for

Best for

Example question

PICOS

Population, Intervention, Comparison, Outcomes, Study design

Evaluating the effectiveness of a treatment against an alternative (or control)

Does cognitive behavioral therapy reduce depression symptoms in adults compared to medication?

PECOS

Population, Exposure, Comparison, Outcomes, Study design

Determining whether a particular exposure is associated with an outcome

Does long-term air pollution exposure increase cardiovascular disease risk in urban adults?

SPIDER

Sample, Phenomenon of Interest, Design, Evaluation, Research type

Analyzing mixed methods research of the experiences, perceptions, or processes of a population

What are the experiences of informal caregivers supporting family members with dementia at home?

PICo

Population, Phenomenon of Interest, Context

Understanding experiences or meanings in a specific context

What are the experiences of nurses providing end-of-life care in hospital settings?

SPICE

Setting, Perspective, Intervention, Comparison, Evaluation

Evaluating services, programs or interventions from the perspective of the population

How effective is a community-based rehabilitation program, from the patient's perspective, in improving functional outcomes compared to standard care?

PCC

Population, Concept, Context

Mapping the breadth of evidence on a topic

What evidence exists on digital health interventions for chronic disease self-management in low-income countries?

If your review is not based on any of the question frameworks available, you can simply select the "Other" option. If you would like to suggest an example of a framework that you think should be included, please feel free to contact us at support@covidence.org. We would be happy to record this as product feedback for consideration in future updates.

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